Abstract B36: Serum adiponectin levels association with acute leukemias: A meta-analysis

Abstract

Abstract Background: Adiponectin, a novel adipokine, secreted by adipocytes in inverse proportion to body fat mass. It is hypothesized that adiponectin exerts a protective role for several type of carcinogenesis, notably those related to obesity including hematological cancers through its anti-apoptotic, anti-inflammatory and anti-angiogenesis properties. Purpose: The aim of this study is to conduct a meta-analysis to investigate the association between serum adiponectin levels and presence of acute leukemia's. Methods: We searched MEDLINE, CIINHAL and COCHRANE databases for studies reporting serum adiponectin levels in the peripheral blood with and without acute leukemia's [Acute lymphoblastic leukemia (ALL)/Acute myleogenous leukemia (AML)]. We included case controls, cohort and cross-sectional studies. We calculated the weighted standardized mean difference (SMD) in serum adiponectin levels between the acute leukemia's patients and control groups. Results: Our search strategy yielded 14 articles and we included 4 studies enrolling 783 participants with 322 patients and 461 controls of matched age, sex and BMI (body mass index). We included 255 ALL patients compared with 240 controls and 67 AML patients compared with 221 controls. The median age of the ALL and AML group compared to controls was 7.39 yrs. (IQR 4.83 – 18.04) and 27 yrs. (IQR 16.03 – 38.08). The median percentage of females of ALL and AML compared to controls was 44.5 (IQR 39.3 – 46.8) and 46.5 (IQR 42.3 – 50.8). The unweighted median serum leptin levels in the ALL and AML groups were 12.65 µg/ml (11.96 – 14.2) and 9.65 µg/ml (6.58 – 12.73) compared to 19.1 µg/ml (17.1 – 20.4) and 27.1 ng/ml (16.03 – 38.08) in the control groups. The SMD of having abnormal serum adiponectin levels of acute leukemia patients compared to controls was -2.77 (95% CI -4.25 - -1.3) P < 0.001. Conclusion: Decreased serum adiponectin levels in acute leukemia's i.e. in both ALL and AML are significantly associated with acute leukemia's. Further investigation into the molecular role of serum adiponectin in carcinogenesis is warranted and would perhaps allow for the use of these biomarkers in early diagnosis of acute leukemia. Citation Format: Vijaya SenaReddy Dendi, Sivakanth Aloor, Dinesh Keerty, Jeffrey Gryn, Jeffrey Gryn. Serum adiponectin levels association with acute leukemias: A meta-analysis. [abstract]. In: Proceedings of the AACR Special Conference: Metabolism and Cancer; Jun 7-10, 2015; Bellevue, WA. Philadelphia (PA): AACR; Mol Cancer Res 2016;14(1_Suppl):Abstract nr B36.