Abstract B28: Racial/ethnic differences in prostate-specific antigen levels among U.S. men with metabolic syndrome: Results from NHANES 2001-2006

Abstract

Abstract Objective: Effect of the interplay between metabolic syndrome and race/ethnicity on prostate specific antigen (PSA) remains unclear. Different definitions of metabolic syndrome (National Cholesterol Education Program [ATP III], International Diabetes Federation [IDF] and World Health Organization [WHO]) may influence PSA disparities. Prevalence of these definitions varies by race/ethnicity. Little is known whether the degree to which serum PSA levels differ is dependent upon the metabolic syndrome definition used, and whether these associations vary by race and ethnicity. Methods: We measured serum PSA (ng/mL) in 3528 adult men >40 years from the National Health and Nutrition Examination Survey (NHANES) 2001-2006. Metabolic syndrome was defined with ATP III, IDF, and WHO criteria. Racial/ethnic groups included non-Hispanic blacks (NHB's), non-Hispanic whites (NHW's) and Mexican-Americans (MA's). We computed adjusted geometric mean PSA by definition of metabolic syndrome and race/ethnicity. Univariate and multivariate regression analysis were performed. Results: Univariate analysis was used to calculate age adjusted geometric mean PSA. Multivariable analysis were adjusted for age, smoking, moderate and vigorous physical activity and plasma-volume. Multivariable analyses showed men classified with ATP III and WHO metabolic syndrome had lower PSA concentrations than those without it (P=0.01 and P=0.03, respectively). Stratifying these associations by race and ethnicity showed that NHW's classified with ATP III and WHO definitions had lower PSA concentrations than those without it (P<0.01 and P=0.04, respectively). Similarly, MA's classified with WHO metabolic syndrome had lower PSA concentration than those without it (P=0.02). No significant differences were detected in PSA levels among NHB's with and without metabolic syndrome. Conclusion: Different criteria for defining metabolic syndrome and its stratification by race and ethnicity had an inverse effect on PSA concentrations among MA and NHW. Our findings highlight the implications when investigating the interplay of different anthropometric measurements and metabolic factors with PSA levels by race and ethnicity. Citation Format: Shailesh M. Advani, David S. Lopez. Racial/ethnic differences in prostate-specific antigen levels among U.S. men with metabolic syndrome: Results from NHANES 2001-2006. [abstract]. In: Proceedings of the Sixth AACR Conference: The Science of Cancer Health Disparities; Dec 6–9, 2013; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2014;23(11 Suppl):Abstract nr B28. doi:10.1158/1538-7755.DISP13-B28