Abstract B16: Two kills with one shot: A biomarker with therapeutic implications in poor prognosis gastric cancers

Abstract

Abstract Bioinformatic approaches are useful to predict significance of gene expression in clinical outcome. Utilizing these non-biased approaches, we now identify that upregulation of aldosterone-regulated sodium reabsorption (ARSR) is seen in a subset of gastric cancers with poor prognosis. Our analysis of a clinical cohort of gastric cancers shows a subunit component of ARSR, SCNNIG, is indeed often overexpressed and is linked to poor survival. To understand this mechanism of the poor survival, overexpression of SCNNIG causes rapid growth of tumors in a xenograft model. Inhibition of aldosterone by spironolactone, a traditional diuretic, specifically kills cancer cells with overexpression of SCNNIG in vitro and in vivo, suggesting a clinical and therapeutic benefit for evaluating patients for this biomarker. Citation Format: Ko Sato. Two kills with one shot: A biomarker with therapeutic implications in poor prognosis gastric cancers [abstract]. In: Proceedings of the AACR International Conference: New Frontiers in Cancer Research; 2017 Jan 18-22; Cape Town, South Africa. Philadelphia (PA): AACR; Cancer Res 2017;77(22 Suppl):Abstract nr B16.