Abstract B16: IL-10 promoter polymorphisms are associated with prostate cancer risk in African Americans

Abstract

Abstract Background: African American men have the highest rates of prostate cancer (PCa) worldwide and immunogenetic studies suggest emerging evidence that prostate inflammation may contribute to prostatic carcinogenesis. Since genetic susceptibility is an etiological factor in PCa, we hypothesize that sequence variants in the promoter region of the IL-10 gene that regulate pro inflammatory cytokines, may modify individual susceptibility to this disease. Methods: four SNPs in the promoter regions with allele frequency differences between Europeans and West Africans were genotyped using pyrosequencing in 538 unrelated men enrolled in a PCa genetic association study at the Howard University Hospital between 2000-2004. Results: SNP rs12122923 was found to have the strongest association using the dominant (p=0.048) and the log additive (p=0.029) genetic models. rs1800871 was found to be associated with PCa using the log additive model(p=0.057). However, after adjusting for age, both SNPs became insignificantly associated with PCa. Conclusions: This study showed an association between IL-10 promoter SNP variation and PCa. This supports the hypothesis that genetic variation in the inflammatory process can contribute to prostate cancer susceptibility. Research supported in part by NIH/NIGMS/MBRS/SCORE grant # S06GM008016. Citation Format: Muneer M. Abbas, Tshela Mason, Luisel Ricks-Santi, Victor Apprey, Rick Kittles, Chiledum Ahaghotu, Georgia Dunston. IL-10 promoter polymorphisms are associated with prostate cancer risk in African Americans. [abstract]. In: Proceedings of the Eighth AACR Conference on The Science of Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; Nov 13-16, 2015; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2016;25(3 Suppl):Abstract nr B16.