Abstract B144: Morphologic consequences for noncapsular lymphoid tissue in the case of malignancy of GERD (Barrett's esophagus)

Abstract

Abstract In this case, the process of development of the Barrett's esophagus and the development of adenocarcinoma as a complication of this disease with involvement of lymphoid tissue with the formation of follicles of different types was studied. Barrett's esophagus (BE) is a precursor of adenocarcinoma of the esophagus, a disease with a growing burden in the Western world. The incidence of BE increased dramatically during the late 20th century and increased morbidity of this disease. Prevalence is between 0.5 and 2.0%. There are risk factors for BE, including obesity and tobacco smoking, but gastroesophageal reflux disease (GERD) is the strongest risk factor. Adenocarcinoma of the esophagus (ACE) is the most common form of esophageal cancer. However, the data from United Kingdom and the Netherlands show that the incidence of BE increased even after monitoring the increase in endoscopy indices. These estimates indicate an increase in the incidence of BE in approximately 65% between 1997 and 2002 and 159% between 1993 and 2005. It is disturbing that the greatest proportionate increase in the diagnosis of BE was in people younger than 60 years, which is consistent with other works from Europe. In analyzing the literature relating to the intrinsic glands of the esophagus and Barrett esophagus, concerned the esophagus's own glands and the presence of a large number of endocrine cells in them. N.I. Kolycheva, R.R. Bektayeva studied at ultramicroscopic level. When studying the work on the lymphoid formations of the esophagus, we can cite, concerning the lymphoid component of the esophagus. At present, the source of lymphocyte infiltration into its proper mucous plate, types of lymphoid formations, has not been studied. To study the lymphoid noncapsular formations of the mucous membrane of Barrett's esophagus, biopsy specimens of Barrett's esophagus were taken. Early only the epithelium of the esophagus was studied, but there was no evidence of a propria of the mucous membrane and lymphoid tissue. Citation Format: Bakhtiyar Talgatuly Azhken. Morphologic consequences for noncapsular lymphoid tissue in the case of malignancy of GERD (Barrett's esophagus) [abstract]. In: Proceedings of the Fourth CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference: Translating Science into Survival; Sept 30-Oct 3, 2018; New York, NY. Philadelphia (PA): AACR; Cancer Immunol Res 2019;7(2 Suppl):Abstract nr B144.