Abstract B142: Colorectal cancer survival, treatment, and recurrence patterns among Hispanic patients in the United States of America, towards a unified consensus: A scoping review

Abstract

Abstract Introduction: Colorectal cancer (CRC) is the third most common cancer excluding skin cancers in the United States (US). Unlike Non-Hispanic White (NHW) populations, cancer is the number one cause of death in Hispanic and/or Latino/a/x (H/L) populations representing 21% of deaths. Despite this, lack of consensus on CRC cancer outcomes exists. To address this gap, we conducted a scoping review to identify patterns of survival, recurrence, and treatment among H/L with CRC in the US. Methods: This scoping review was conducted in accordance with the JBI methodology for scoping reviews, the proposed framework by Arksey & O’Malley with Levac’s enhancement, and in line with the PRISMA extension for Scoping Reviews. The MEDLINE (PubMed), Embase and Scopus databases were searched for peer-reviewed observational studies published in English that included data from H/L with CRC residing in the US and territories (e.g., Puerto Rico). We included papers published until November 30th, 2022. A two-stage screening process was conducted via two independent reviewers. A data extraction instrument was developed following JBI recommendations. Descriptive numerical summaries, graphical representations and narrative review of the extracted literature was done. Results: We identified 16,074 studies of which 5,458 were duplicates, and 10,373 were irrelevant, with 243 full-text studies assessed for eligibility. After excluding 159 studies, a total of 84 publications were abstracted. Differences in survival was the most assessed outcome with 68 studies, of these, 15 publications also provided information in treatment. 19 studies reported exclusively on treatment patterns. No peer-reviewed publications provided specific point estimates for recurrence. Cohort study designs were the most prevalent (84.52%), followed by Cross-Sectional/Ecological designs (14.29%) and 1 case-only study. Population-based registries (61.9%) and US-nation-wide databases (16.67%) were the most cited data sources. There was heterogeneity in the studied H/L populations, with over-representation of California, Texas, and Florida. Of the studies that evaluated disparities in survival and/or mortality, 17 reported a more favorable outcome, 21 an unfavorable outcome, and 19 found no difference for H/L versus NHWs. Interestingly, only 30 of the studies that provided a specific point estimate to compare H/L to NHW controlled for Socioeconomic Status (SES) in the analysis, and only 4 took Nativity and/or country of origin into consideration. Conclusion: This is the first study to provide a comprehensive review of the patterns of survival, treatment, and recurrence for H/L with CRC living in the US. There is lack of research in patterns of recurrence among H/L. Also, H/L have heterogeneous survival and mortality outcomes when compared to NHW, likely driven by lack of consideration of key determinant like SES and/or nativity; thus, standardization of these covariates is paramount. The opportunity to conduct a meta-analysis for patterns of survival and mortality was also detected. Citation Format: Joel Sanchez Mendez, Roger Li, Symone Moore, Elizabeth Quino, Wei Xiong, Mariana C. Stern. Colorectal cancer survival, treatment, and recurrence patterns among Hispanic patients in the United States of America, towards a unified consensus: A scoping review [abstract]. In: Proceedings of the 16th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2023 Sep 29-Oct 2;Orlando, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2023;32(12 Suppl):Abstract nr B142.