Abstract B132: Vitamin D and breast cancer health disparities: A rapid scoping review investigating the relationship between vitamin D and breast cancer mortality in African American women stratified by molecular subtype

Abstract

Abstract Introduction: Black women face disproportionate mortality rates from breast cancer because of being more likely to face aggressive breast cancer prognosis and metastasis. Past research findings showed that low vitamin d serum levels are a risk factor for certain types of breast cancer (TNBC, HR+ etc.). Vitamin D deficiency is particularly prevalent amongst black individuals and black women are more likely to experience metastasis and aggressive breast cancer prognosis. However, there is a lack of research on black women that investigates the relationship between vitamin d serum levels and mortality, stratified by prognosis category.   Specific Aim and Hypothesis:  This rapid scoping review is developed to describe the nature, number, and scope of published research articles measuring the association between vitamin D and mortality in black breast cancer patients based on the molecular subtype. a)     Is there a gap in literature to determine if vitamin D has an impact on mortality in black women with breast cancer? If there is an impact, does it vary based on molecular subtype in black women?   Methods: A rapid scoping review will be conducted. Studies that do not provide the following data on African American women with breast cancer will be excluded: breast cancer molecular subtype, mortality status, and vitamin d serum levels pre and post diagnosis. Articles will be reviewed if they were published after 2013 to maintain scientific relevance and must be in the English language. The databases used to conduct the search will be PubMed, Cochran, CINAHL, JBI, web of science, TRIP, and science direct. Studies will be analyzed together based on the type of study (ex. Case-control vs cohort) and when the vitamin D measurements were taken (ex. Pre-diagnosis vs post-diagnosis).   Public Health Implication Identifying potential factors such as lack of vitamin D that contribute to high cancer morbidity and mortality in black women with breast cancer will allow different mechanisms for reducing this cancer disparity.   Citation Format: Adrienne Vaughn. Vitamin D and breast cancer health disparities: A rapid scoping review investigating the relationship between vitamin D and breast cancer mortality in African American women stratified by molecular subtype [abstract]. In: Proceedings of the 16th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2023 Sep 29-Oct 2;Orlando, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2023;32(12 Suppl):Abstract nr B132.