Abstract
Abstract Objective: Prostate cancer is a prevalent disease among men worldwide, and early detection plays a crucial role in improving patient outcomes. It has been suggested that chronic stress could increase the risk of developing prostate cancer, however, the association between prostate-specific antigen (PSA) levels and chronic stress, as measured by allostatic load (AL) - remains poorly understood. Hence, this study aims to investigate the association between PSA levels and allostatic load among Nigerian men. Methods: A cross-sectional study was conducted involving 80 males in Ota, Nigeria. Data on demographic characteristics, lifestyle factors, medical history, and occupational stressors were collected through structured questionnaires. Blood samples were obtained to measure PSA levels, and the allostatic load was assessed using a composite index based on physiological indicators such as blood pressure, lipid profile, glycemic control, and inflammatory markers. Multiple linear regression analysis will be used to examine the association between PSA, AL, lifestyle factors, and socioeconomic status. Expected Results: We hypothesize a positive correlation between PSA levels and allostatic load among Nigerian men. Hence, this suggests that higher levels of allostatic load, an indicator of chronic stress and physiological dysregulation, may be associated with elevated PSA levels. Conclusion: If a positive correlation between PSA and allostatic load is established, it could suggest that managing chronic stress and improving physiological regulation might have a positive impact on prostate health. Citation Format: Olanike Olowokere, Olutola Olasehinde, Opeyemi C. De Campos, Ayomide Adebesin, Titilayomi Bisi-Adeniyi, Olawole Tolulope, Abimbola Onyia, Oluwakemi Rotimi, Solomon Oladapo Rotimi. Association of allostatic load with prostate-specific antigen level among Nigerian men [abstract]. In: Proceedings of the 16th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2023 Sep 29-Oct 2;Orlando, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2023;32(12 Suppl):Abstract nr B120.
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