Abstract B12: Macrophage inhibitory cytokine-1 as a potential biomarker for racial disparity in prostate cancer

Abstract

Abstract Macrophage inhibitory cytokine-1 (MIC-1) has drawn significant attention due to its association with the development and progression of prostate cancer (PCa). Recent studies have projected MIC-1 as a potential biomarker for various disease conditions including PCa. Given evidence for more aggressive disease among African American (AA) men, we aimed to investigate if MIC-1 was differentially expressed among AA and Caucasian men. We measured serum MIC-1 levels by sandwich ELISA in samples collected during the diagnosis of PCa (pre-surgical). Our data consists of information on 40 Caucasian and 40 AA men between the ages of 43 and 75 years (Median = 60 years). Based on the analysis of log transformation of the data, significant differences among the two races were found, with AA having higher MIC-1 expression (Median 1220.4 versus 790.8, p=0.0001), Gleason scores (Median 7 versus 6, p=0.0009) and PSA (Median 6.72 versus 6.35 ng/ml, p = 0.04) than Caucasians. No differences in age or pathological stage of disease were observed between groups (p > 0.05). Higher levels of MIC-1 and Gleason scores were associated (p<0.001 and p<0.05, respectively) with older patients among Caucasians. In contrast, among AA samples, MIC-1 and Gleason scores were not differentially expressed based on age. This phenomenon was not observed when examining PSA expression levels by age among AA and Caucasians. Altogether, these observations indicate that MIC-1 may play a role in more aggressive disease among younger AA men and addition of MIC−1 may help to improve the discrimination of aggressive disease at least in AA men. Further analysis of the mechanism of activity of MIC-1 and validation in a larger dataset is required. Citation Format: Dev Karan, Seema Dubey, Jo Wick, Ossama Tawfik, Guru Sonpavde, Peter VanVeldhuizen. Macrophage inhibitory cytokine-1 as a potential biomarker for racial disparity in prostate cancer. [abstract]. In: Proceedings of the Eighth AACR Conference on The Science of Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; Nov 13-16, 2015; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2016;25(3 Suppl):Abstract nr B12.