Abstract B100: Alcohol consumption and risk of renal cell cancer: The NIH-AARP Diet and Health study

Abstract

Abstract Introduction: There is substantial epidemiologic evidence that alcohol consumption is positively associated with the development of several cancers, notably in the breast, mouth, pharynx and laryngeal. Epidemiologic studies have reported inconsistent findings on the relationship between alcohol consumption and risk of renal cell cancer (RCC), prospective cohort studies have reported statistically non-significant inverse association between alcohol consumption and the risk of RCC. Therefore, we investigated the association between alcohol consumption and RCC in the NIH-AARP Diet and Health study. Methods: We analyzed 490,159 eligible men (n=292,101) and women (n=198,058) in the prospective NIH-AARP Diet and Health study. At baseline, we assessed alcohol and other nutrient intakes with a food frequency questionnaire, and collected data on demographics, lifestyle, and medical history. We used Cox proportional hazards models to calculate relative risks (RR) and 95% confidence intervals (CI), adjusting for age, race, height, body mass index (BMI), marriage status, physical activity, smoking history, history of diabetes and hypertension, and intakes of protein and energy. Results: During an average of 7 years of follow-up, we identified 1,106 cases of RCC: 811 were men, 295 were women. 21% of the men and 30% of the women did not drink alcohol. The percentage of current smokers increased with amount of alcohol consumed for both sexes. Alcohol was inversely associated with risk of RCC. Per 10g/day increment, RR was 0.96 (95% CI:0.93–0.99). There was a significant interaction by sex. Alcohol showed a null association with RCC in men: the multivariate RR (95%CI) was 0.96 (0.93–1.00) for every 10g increase in alcohol consumption per day. The findings were similar for different alcoholic beverage types. The multivariate RR (95%CI) was 0.95 (0.90–1.00) for every 1 serving of beer per day, 1.05 (0.94–1.16) for every 1 serving of wine per day, and 0.96 (0.92–1.01) for every 1 serving of liquor per day. However, alcohol showed an inverse association with RCC in women: the multivariate RR (95%) was 0.60 (0.45–0.80) for every 10g increase in alcohol consumption per day. The multivariate RR (95%CI) was 0.85 (0.53–1.38) for every 1 serving of beer per day, 0.40 (0.22–0.74) for every 1 serving of wine per day, and 0.68 (0.45–1.01) for every 1 serving of liquor per day. There was no significant alcohol-renal cell cancer interactions observed with BMI, smoking or oral contraceptives. Conclusion: Alcohol consumption is inversely associated with the risk of renal cell cancer only in women. Citation Information: Cancer Prev Res 2010;3(1 Suppl):B100.