Abstract B096: Cigarette smoking and prostate cancer aggressiveness among African and European American men

Abstract

Abstract Background: Smoking is a modifiable lifestyle factor linked to prostate cancer (PCa) risk, but its association with PCa aggressiveness is unclear. Further, African-American men are likelier to smoke and be at risk for PCa. Therefore, we examined racial disparities in the association between cigarette smoking and PCa aggressiveness. Methods: Data for this study came from the North Carolina-Louisiana Prostate Cancer Project, a registry-based cohort study of incident PCa cases from 2004-2009 (n = 1,457). We defined PCa aggressiveness as high (Gleason score ≥ 8, Gleason score = 7 and TNM T3-T4, or prostate-specific antigen (PSA) score > 20 ng/mL) or low (Gleason score < 7, TNM T1-T2, and PSA < 10 ng/mL). We classified cigarette smoking as current, former, or never. Our analyses used multivariable logistic regression to estimate adjusted odds ratios (OR) and 95% confidence intervals (CI). Results: One-third (35%) of PCa cases were high-aggressive. Half (48%) of the study sample was African-American. Current smoking, but not former smoking, was associated with high-aggressive PCa compared to never (OR = 2.2; 95% CI [1.5, 3.3]). African-Americans who currently smoked had higher odds of high-aggressive PCa than those who never smoked (OR = 3.2; 95% CI [1.9, 5.4]), as did those who formerly smoked (OR = 1.8; 95% CI [1.2, 2.3]). However, smoking did not significantly predict PCa aggressiveness in European-Americans. Conclusion: Cigarette smoking is associated with PCa aggressiveness, an association moderated by race. Future research should investigate the biological and social effects of smoking and PCa aggressiveness between racial groups. Citation Format: Edgar T. Ellis, Brian J. Fairman, Shelbie D. Stahr, L. Joseph Su, Ping-Ching Hsu. Cigarette smoking and prostate cancer aggressiveness among African and European American men [abstract]. In: Proceedings of the 16th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2023 Sep 29-Oct 2;Orlando, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2023;32(12 Suppl):Abstract nr B096.