Abstract B088: Association of neighborhood gentrification with prostate cancer in African American and European American men

Abstract

Abstract Abstract Background: Prior studies showed that neighborhood deprivation increases the risk of lethal prostate cancer. However, the role of neighborhood gentrification in prostate cancer development and outcome remains poorly understood. We examined the relationships of gentrification with prostate cancer in a diverse cohort. Methods: This case-control study included 769 cases [405 African American (AA), 364 European American (EA) men] and 1023 controls (479 AA, 544 EA), with 219 all-cause and 59 prostate cancer-specific deaths among cases. Geocodes were linked to a neighborhood gentrification index (NGI) derived from US Census data. Cox and logistic regression were used to determine associations between NGI, as continuous or quintiles (Q), and outcomes. Results: Adjusting for individual socioeconomic status (SES), continuous NGI was associated with prostate cancer among all men (odds ratio (OR) 1.07, 95%CI 1.01-1.14). AA experienced the highest odds of prostate cancer when residing in tracts with moderate gentrification (Q3 OR 1.79, 95%CI 1.11-2.88). However, EA men experienced a reduced risk of regional/metastatic cancer (risk ratio 0.62, 95%CI 0.40-0.97) with increased gentrification, adjusting for SES. Continuous NGI was associated with mortality among men presenting with localized disease (all-cause HR 1.10, 95%CI 1.01-1.20; disease-specific SHR 1.16, 95%CI: 1.01-1.33). Conclusions: Findings show that neighborhood gentrification modestly associates with prostate cancer and mortality in this diverse population. They suggest that changing neighborhood socioeconomic environments may affect prostate cancer risk and outcome, likely through multifactorial mechanisms. Citation Format: Catherine M. Pichardo, Adaora Ezeani, Margaret Pichardo, Tanya Agurs-Collins, Tiffany M. Powell-Wiley, Brid Ryan, Tsion Minas, Maeve Bailey-Whyte, Wei Tang, Tiffany H. Dorsey, William Wooten, Christopher A. Loffredo. Association of neighborhood gentrification with prostate cancer in African American and European American men [abstract]. In: Proceedings of the 16th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2023 Sep 29-Oct 2;Orlando, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2023;32(12 Suppl):Abstract nr B088.