Abstract A60: Risk of developing invasive breast cancer risk in Hispanic women: A look across Hispanic subgroups.

Abstract

Abstract Background: Breast cancer is a significant public health threat to Hispanic women in the United States (US). While evidence on the burden of breast cancer among US Hispanic women is available, it is important to assess the heterogeneity in breast cancer risk among Hispanic women of different origins. To address this gap, the purpose of our study was to assess the distribution of breast cancer risk among women from six Hispanic subgroups. Methods: Using data from the 2000 and 2005 National Health Interview Survey (NHIS) Cancer Control Modules, we assessed the Breast Cancer Risk Assessment Tool (BCRAT) 5-year and lifetime risk of developing invasive breast cancer among Mexican/Mexican-American (n=1,932), Puerto Rican (n=385), Cuban/Cuban-American (n=274), Dominican (Republic) (n=123), Central/South American (n=468), Other Hispanic (n=204) and non-Hispanic whites (n=16,131). Multivariate linear regression models used to compare the distribution of both the BCRAT 5-year and lifetime absolute breast cancer risk between: i) Hispanic versus non-Hispanic white women and ii) Hispanic subgroups. Results: Hispanic women, overall, had a significantly lower mean BCRAT 5-year risk and lifetime risk estimates compared to non-Hispanic whites (p<0.001). Cuban/Cuban-American women had a significantly higher BCRAT 5-year risk (p<0.05), while Dominican women had a higher lifetime risk, compared Mexican/Mexican-American women (p<0.001). A significantly lower proportion of Hispanic women, overall, were at high risk of breast cancer, based on both the BCRAT 5-year and lifetime risk estimates, compared to non-Hispanic white women (p<0.001). Approximately 2.6% of all Hispanic women had BCRAT 5-year risk ≥1.67% and only 0.2% had a lifetime risk ≥20.0%. A greater proportion of Central/South American women had a BCRAT 5-year risk ≥1.67 compared to Mexican/Mexican-American women (p<0.001). Conclusion: Our findings indicate that, based on the BCRAT, Hispanic women have a significantly lower risk of developing invasive breast cancer, compared to non-Hispanic white women; furthermore, we highlight differences in the BCRAT risk among women in different Hispanic subgroups. Lastly, we provide national estimates of the number of Hispanic women from six key subgroups, who would be eligible for prophylactic breast cancer chemoprevention as recommended by ASCO and NCCN. Future studies are warranted that further investigate differences in breast cancer risk as well as important breast cancer risk factors between Hispanics women of different origins. Citation Format: Matthew P. Banegas, Mei Leng, Barry I. Graubard, Leo S. Morales. Risk of developing invasive breast cancer risk in Hispanic women: A look across Hispanic subgroups. [abstract]. In: Proceedings of the Fifth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2012 Oct 27-30; San Diego, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2012;21(10 Suppl):Abstract nr A60.