Abstract
Abstract The association between physical activity and colorectal adenoma is equivocal. This study was designed to assess the relationship between various physical activity types and colorectal adenoma recurrence in a pooled sample of participants from the Wheat Bran Fiber and Ursodeoxycholic Acid phase III clinical trials with available data from the baseline Arizona Activity Frequency Questionnaire and a follow-up colonoscopy (n=1,730). Logistic regression modeling was used to estimate the relationship between sedentary, recreational, and household activity on colorectal adenoma recurrence overall and stratified by gender. No statistically significant associations were found between any activity type and colorectal adenoma recurrence overall however, males with the highest sedentary time demonstrated a statistically significant 45% higher odds of adenoma recurrence. Compared to the lowest quartile of sedentary time, the ORs (95% CIs) for the second, third, and fourth quartiles among men were 1.31 (0.93, 1.84), 1.47 (1.04, 2.09) and 1.45 (1.02, 2.06) respectively (P trend=0.03). In males, those with low recreational activity and high sedentary time was also associated with greater risk for recurrent adenoma, with an OR (95% CI) of 1.41(1.00-2.00) for high sedentary time/low recreational activity compared to the reference group (low sedentary time/low recreational activity). Our results suggests that sedentary time is associated with a higher risk of colorectal adenoma recurrence among men, supporting a role for sedentary lifestyle in the early stages of carcinogenesis. Efforts to intervene on sedentary time should be evaluated as a method for reducing recurrent adenomas. Citation Format: Christine L. Sardo, Erin L. Ashbeck, Elizabeth A. Hibler, Denise Roe, Robin B. Harris, Martin Cisneroz, Peter Lance, Maria Elena Martinez, Cynthia A. Thomson, Patricia A. Thompson, Elizabeth T. Jacobs. Sedentary behavior is associated with colorectal adenoma recurrence in men. [abstract]. In: Proceedings of the Twelfth Annual AACR International Conference on Frontiers in Cancer Prevention Research; 2013 Oct 27-30; National Harbor, MD. Philadelphia (PA): AACR; Can Prev Res 2013;6(11 Suppl): Abstract nr A48.
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