Abstract A35: Metabolomic profiling and the biochemical basis of prostate cancer racial disparity.

Abstract

Abstract African American (AA) men have an approximately 60% higher incidence of prostate cancer and are at 2 times greater risk of dying of prostate cancer than European Americans (EA). Environmental and socio-economic factors as well as a number of genetic alterations have been previously interrogated as possible explanations for this disparity. Currently, little is known about the specific biological pathway differences in prostate cancer between AA and EA men that may help explain the greater burden borne by AA men with this disease. In this study, we seek to unravel and compare the prostate cancer metabolome of AA and EA men by employing state of the art metabolomic profiling and bioinformatic techniques. Based on the premise that metabolites are end products of enzyme action, we sought to identify a racially distinct biochemical signature for prostate cancer. Fifty-six prostate cancer tissue samples from AA and EA men and their adjacent benign tissues (i.e., matched normal/tumor pairs) were analyzed using an unbiased liquid chromatography-coupled mass spectrometry approach. Differential metabolites were mapped into pathways and combined with bioinformatics-based bioprocess mapping to categorize metabolic differences observed in cancers of AA and EA origin. Our data indicate a specific and largely mutually exclusive metabolic signature for AA and EA derived prostate cancers. These findings may have important clinical implications and, importantly, shed new light on the biological basis of prostate cancer racial disparity. Citation Format: Shaiju Kakkandan VareedKatrin Panzitt, Sumanta Basu, Vasanta Putluri, Tiffany Dorsey, Tiffany Wallace, Nagireddy Putluri, Sayeeduddin Mohammed, Michael Ittmann, Rick Kittles, George Michailidis, Stefan Ambs, Ganesh Palapattu, Arun Sreekumar. Metabolomic profiling and the biochemical basis of prostate cancer racial disparity. [abstract]. In: Proceedings of the Fifth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2012 Oct 27-30; San Diego, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2012;21(10 Suppl):Abstract nr A35.