Abstract A35: Diagnostic performance and timing of post-treatment 18F-FDG PET/CT for head and neck cancer surveillance: A meta-analysis of reported studies

Abstract

Abstract Purpose: The aims of this meta-analysis are to evaluate the diagnostic performance and to explore the optimal timing of post-treatment 18F-FDG PET/CT for HNSCC. Methods: January 2010 to August 2016 was the range for study selection. Subgroup analyses were performed for local/regional failure stratified by treatment-to-scan time interval of ≤3 vs. >3 months. Results: Twenty-four studies (2,256 patients) were included. Compared to ≤3 months, 18F-FDG PET/CT performed >3 months showed significantly improved sensitivity (87% vs. 60%, p=0.020) and specificity (93% vs. 84%, p<0.001) for identifying local failure and marginally improved sensitivity for regional failure (79% vs. 56%, p=0.100). The specificity for regional failure was equally high for >3 months vs. ≤3 months (95% vs. 97%, p=0.35). Conclusions: This meta-analysis showed high NPV but modest PPV for post-treatment 18F-FDG PET/CT for local and regional failure. Sensitivity is improved if performed >3 months for local failure and marginally improved for regional failure. Citation Format: Erin T. Wong, Adam A. Dmytriw, Eugene Yu, John Waldron, Rouhi Fazelzad, John de Almeida, Patrick Veit-Haibach, Brian O’Sullivan, Wei Xu, Shao Hui Huang. Diagnostic performance and timing of post-treatment 18F-FDG PET/CT for head and neck cancer surveillance: A meta-analysis of reported studies [abstract]. In: Proceedings of the AACR-AHNS Head and Neck Cancer Conference: Optimizing Survival and Quality of Life through Basic, Clinical, and Translational Research; 2019 Apr 29-30; Austin, TX. Philadelphia (PA): AACR; Clin Cancer Res 2020;26(12_Suppl_2):Abstract nr A35.