Abstract
Abstract Nanoparticels have been researched broadly as new generation of diagnostics, imaging agents, and drugs for detecting and treating cancer. We previously developed PEGylated small hydrophilic carbon clusters (PEG-HCCs) and reported that PEG-HCCs conjugated with paclitaxel (PTX/PEG-HCCs) is a stable effective drug delivery system with minimal toxicity. Here, we describe the establishment of targeted nanovectors by simply mixing PTX/PEG-HCCs with cetuximab (ImClone Systems), an anti-epidermal growth factor receptor (EGFR) monoclonal antibody. The specificity of this EGFR targeted method of delivery of PTX/PEG-HCCs was demonstrated in mice implanted subcutaneously on opposing flanks with EGFR expressing, OSC-19 (head and neck squamous cell carcinoma: HNSCC) cells and non-EGFR-expressing MCF-7 cells in a nude mouse. The targeted nanovector system, Cet/PTX/PEG-HCCs, showed greater efficacy superior than PTX/PEG-HCCs on OSC-19 tumor growth, but not on MCF-7 tumors. Cet/PTX/PEG-HCCs also showed greater growth inhibition prolonged survival compared to PTX or PTX/PEG-HCCs in an orthotopic nude mouse model of human HNSCC. These results suggested that Cet/PTX/PEG-HCCs can targeted to HNSCC overexpressing EGFR cells. In addition, Cet/PTX/PEG-HCCs were found to radiosensitize HNSCC cells both in vitro and in vivo. Cet/PTX/PEG-HCCs plus radiation inhibited tumor growth and prolonged survival in vivo. This work is highly significant as success would allow for targeted chemotherapy for HNSCC by simply mixing commercially available drugs and antibodies with a nanovector solution. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2011 Nov 12-16; San Francisco, CA. Philadelphia (PA): AACR; Mol Cancer Ther 2011;10(11 Suppl):Abstract nr A145.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
