Abstract A131: Cumulative burden of fatty liver and kidney cancer in young-aged men: A national population-based study

Abstract

Abstract Introduction Kidney cancer is considered as a metabolic disease due to its association with metabolic problems including obesity and metabolic syndrome. The association of kidney cancer with metabolic syndrome components and higher association in young-aged male population has been reported. Recent trends show an increasing incidence of kidney cancer, coupled with rising costs due to the development of new drugs. In light of these factors, identifying modifiable factors becomes a meaningful endeavor from a public healthcare perspective. The aim of this study was to determine the association of kidney cancer with cumulative burden of fatty liver in young-aged men using fatty liver index (FLI). Methods Korean National Health Insurance Service database were used. A total of 1,007,906 men aged ≥ 20 years and < 40 years who received four consecutive check-ups from January 2009 to December 2012, excluding those with missing data, history of malignancy, and those who died or diagnosed with cancer within one year after their last check-up were analyzed. They were followed up to the diagnosis of kidney cancer or death until December 2020. Non-alcoholic fatty liver disease (NAFLD) was defined as FLI ≥ 60. Results With increasing cumulative frequency of FLI >60, there was a noticeable rise in the proportion of subjects who were current smokers and heavy drinkers. Furthermore, BMI, WC, glucose and lipid profiles (excluding HDL) demonstrated an upward trend. HR in subjects with mean 30 ≤ FLI < 60 was 1.447 (95% CI 1.26-1.853) and 2.391 (95% CI 1.986-2.879) in those with mean FLI ≥ 60. As the cumulative frequency increased, HR for kidney cancer increased. A group that initially had FLI ≥ 60, and FLI decreased below 60 at the last check-up showed lower HR compared to a group that had FLI ≥ 60 on both measurements (HR 1.374 vs. 2.430). Furthermore, this HR was lower than the group that had FLI < 60 initially but increased to ≥ 60 (1.374 vs. 1.653). Conclusion This study showed the association between cumulative burden of fatty liver using FLI and kidney cancer in young-aged men. As the cumulative burden of NAFLD increased, the incidence of kidney cancer increased. In the cases with initial high FLI (≥ 60) and final low FLI (< 60) showed lower HR compared to the cases with high FLI at initial and final measurements. Citation Format: Hee Yeon Lee, Kyung-Do Han, Hyuk-Sang Kwon. Cumulative burden of fatty liver and kidney cancer in young-aged men: A national population-based study [abstract]. In: Proceedings of the AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics; 2023 Oct 11-15; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2023;22(12 Suppl):Abstract nr A131.