Abstract A111: Racial differences in the relationship between dimensions of smoking exposure and lung cancer risk: A pooled analysis from the International Lung Cancer Consortium Study

Abstract

Abstract Lung cancer incidence is higher among African Americans (AAs) compared with European Americans (EAs) and Asian Americans (AsA) in the United States. Although there has been a significant reduction in cigarette smoking, racial disparities in tobacco use and lung cancer risk persist in the US. While data exists suggesting that African Americans have a higher risk of lung cancer at lower cigs per day, data independently linking each measure of smoking exposures and lung cancer risk among AAs compared with EAs and AsA are limited. We conducted a pooled case-control study of 19,965 cases and 331,478 controls from 10 population-based case-control and cohort studies from the US within the International Lung Cancer Consortium (ILCCO). We used logistic regression models to examine associations between several smoking dimensions (status, age at initiation, duration, intensity, pack-years and cessation) and lung cancer risk. Overall, the magnitude of the relationship between each dimension of smoking exposure and lung cancer risk was higher among AAs. AAs who were light smokers had an increased odds of lung cancer compared with EAs and AsA (1-10 cigs/day: AA OR = 5.66, 95% CI: 4.73-6.76; EA OR = 2.86, 95% CI: 2.58-3.17; AsA OR = 2.82, 95% CI: 2.35-3.39) after adjustment for age, gender and study center. Similar trends were observed for age at smoking initiation (age at smoking initiation 25+ years: AA OR = 7.54, 95% CI: 6.35-8.96; EA OR = 5.49, 95% CI: 4.99-6.03; AsA OR = 4.00, 95% CI: 3.44-4.66). This study suggests that racial and ethnic differences between individual dimensions of smoking exposure and lung cancer exist. In general, at equal levels of exposure, AAs seem to be more susceptible than EAs and AsA. Future work will assess if these findings hold following adjustment for population specific smoking patterns. Citation Format: Rony F. Arauz, Neal D. Freedman, Maki Inoue-Choi, Ann G. Schwartz, Brid M. Ryan. Racial differences in the relationship between dimensions of smoking exposure and lung cancer risk: A pooled analysis from the International Lung Cancer Consortium Study [abstract]. In: Proceedings of the Twelfth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2019 Sep 20-23; San Francisco, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl_2):Abstract nr A111.