Abstract A110: Racial disparities in transitional cell carcinoma of the bladder: A population-based study

Abstract

Abstract Introduction: Bladder cancer is among the most common cancers in the U.S. with an estimated 81,190 new cases diagnosed in 2018 as well as 17,240 estimated deaths. The vast majority, around 90%, of bladder cancer cases are transitional cell carcinoma. Due to the significant burden of the disease, and disparities in access to medical care, we aim to study the survival of patients diagnosed with transitional cell carcinoma based on ethnicity. Methods: Data of White and Black patients with transitional cell carcinoma of the bladder diagnosed between 1973 and 2014 were obtained using the SEER database. We compared the overall and cancer-specific survival of patients using Kaplan-Meier test and Cox models. Results: We reviewed a total of 199,535 patients with transitional cell carcinoma of the bladder, of whom 10,263 were blacks, while the others were whites. The median overall survival of white patients was 103 months (95%CI, 102.0.34-103.966), which was significantly better than the overall survival of black patients, which was 64 months (95%CI, 60.373-67.627). Bladder cancer-specific survival was also better for whites when compared to blacks. When we adjusted age, sex, grade and stage of cancer, and undergoing surgery for bladder cancer, being black was associated with worse overall survival outcomes and cancer-specific survival outcomes (HR=1.263, 95%CI [1.227-1.300], P<.001) and (HR=1.396, 95%CI [1.342-1.451] P<.001), respectively. Conclusions: Our results show that significant differences in cancer-specific survival between ethnicities with the majority of diagnosed patients being Whites, while Blacks are suffering from worse survival outcomes. More research can shine a light on the underlying reasons why ethnicity is a significant factor affecting the survival of patients with bladder cancer. Citation Format: Mohamed M. Gad, Anas M. Saad, Mariam A. Obaid, Muneer J. Husseini. Racial disparities in transitional cell carcinoma of the bladder: A population-based study [abstract]. In: Proceedings of the Eleventh AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2018 Nov 2-5; New Orleans, LA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl):Abstract nr A110.