Abstract A092: All of Us research program: Health equity and precision medicine

Abstract

Abstract The All of Us Research Program aims to accelerate health research and medical breakthroughs, enabling individualized prevention, treatment, and care for all. All of Us is building a large and inclusive cohort, with a goal of enrolling one million or more participant partners that reflect the rich diversity of the United States. Health equity is a core value of the program with a focus on engaging diverse communities in safe, protected ways. All of Us aims to include and build trust with those previously underrepresented in biomedical research while helping to improve the lack of diversity in genomic research. Furthermore, unlike research studies that focus on one disease or group of people, All of Us is working to improve health care through research by creating a widely accessible, disease agnostic resource, known as the Researcher Workbench, for researchers to make discoveries. To date, we have equipped more than two thousand researchers nationwide with health data from diverse populations. The Researcher Workbench is also uniquely positioned to empower cancer research, with 150+ projects focused in oncology. More broadly, the diversity of the projects show how the program’s data can be utilized for multidisciplinary research across various topic areas including cancer, genomics, health equity, and more to advance precision medicine in ways that reduce health disparities. Available data types include genomics, electronic health records, surveys (social determinants of health, lifestyle, etc.), physical measurements, and wearables. We aim to make these data broadly accessible to drive research about various diseases, especially those where health disparities persist.With an emphasis on engagement and recruitment of populations historically underrepresented in biomedical research and equity-focused data access for research in a diverse dataset, the All of Us Research Program can help enable a deeper understanding of disease biology and ultimately more precise approaches to care for all. Citation Format: JoAnn Smith. All of Us research program: Health equity and precision medicine [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr A092.