Abstract A063: Social context and cancer: Stress and quality of life in rural-dwelling Latina cancer survivors

Abstract

Abstract Introduction: Latina breast and gynecologic cancer survivors (LCS) experience higher levels of distress and lower quality of life compared to non-Latinos. This randomized control trial examined the effect of a promotora-led 10-week Spanish language support program on levels of stress and cancer-related quality of life (QOL) in LCS. Methods: Fifty-nine LCS were randomized to receive the 10-week intervention (n=30) or to a delayed-intervention control (n=29) group. Measures were assessed at baseline (T1) and upon completion of the intervention period (T2) and included the: short Hispanic Stress Inventory (HSI) [subscales: extra-familial and intra-familial stress]-version 2, the Functional Assessment of Cancer Therapy (FACT-G) QOL scale [subscales: physical (P-QOL), functional (F-QOL), emotional (E-QOL), social (S-QOL)], the FACT-Fatigue QOL scale, and a demographic survey. RESULTS: No statistically significant differences were observed between the intervention and control groups for any of the outcome variables. Perceived stress scale [t(57)=0. 37, p=0. 72], Hispanic Stress Inventory extrafamilial subroup [t(57)=1. 8, p=0. 09], and Hispanic Stress Inventory intrafamilial subgroups [t(57)=1. 5, p=0. 18]. Results for quality of life subscales were physical [t(57)=-1. 66, p=0. 10], social [t(47)=-0. 32, p=0. 75], emotional [t(57)=-0. 41, p=0. 97], and functional [t(57)=1. 38, p=0. 17] well-being. Exploratory analyses a mediating effect of extrafamilial stress on a significant relationship between Spanish-only language and lower EQOL. Conclusions: The effect of the promotora-led intervention was not significant. However, an exploratory mediation analyses identified a significant role of extrafamilial (ethnic-based) stress among Spanish-only speakers with EQOL. A detailed presentation of study findings, including a critique of the intervention design and implications for the effect of social context on cancer-related outcomes will be discussed. Citation Format: Rachel M Ceballos, Genoveva Ibarra, Monica Escareno, Nora Gonzalez, Nathan Marchello. Social context and cancer: Stress and quality of life in rural-dwelling Latina cancer survivors [abstract]. In: Proceedings of the Twelfth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2019 Sep 20-23; San Francisco, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl_2):Abstract nr A063.