Abstract A04: HOXB13 regulates androgen receptor expression in prostate cancer

Abstract

Abstract The androgen receptor (AR), a member of the nuclear receptor superfamily of ligand-regulated transcription factors, plays a pivotal role in the initiation and progression of prostate cancer. HOXB13, a prostate-specific homeodomain-containing transcription factor, interacts with AR to regulate the cellular response to androgens (Norris et al. Mol Cell 2009). The overexpression of HOXB13 in LNCaP and VCaP cells led to an increased expression of AR at the mRNA and protein levels; upon the reduction of endogenous HOXB13 by siRNA in LNCaP cells and VCaP cells, the amount of AR decreased at the mRNA and protein levels. Conversely, when AR was knocked down with siRNA in LNCaP cells, the level of HOXB13 proteins increased but not mRNA level, indicating that HOXB13 promotes the expression of AR, and AR promotes HOXB13 degradation. HOXB13 promoting AR expression might be one of the mechanisms by which HOXB13 regulates AR function. Note: This abstract was not presented at the conference. Citation Format: Shuangling Chen, William B. Isaacs. HOXB13 regulates androgen receptor expression in prostate cancer. [abstract]. In: Proceedings of the Third AACR International Conference on Frontiers in Basic Cancer Research; Sep 18-22, 2013; National Harbor, MD. Philadelphia (PA): AACR; Cancer Res 2013;73(19 Suppl):Abstract nr A04.