Abstract 9931: Baseline Characteristics of Patients with Peripartum Cardiomyopathy; Mortality versus Left Ventricular Ejection Fraction Recovery Groups

Abstract

Introduction: Data about long term outcomes among patients with peripartum cardiomyopathy (PPCM) is limited. According to the 2018 ESC guideline for the management of cardiovascular disease during pregnancy, three factors are associated with adverse outcomes including baseline LVEF < 30%, LVEDD ≥ 60 mm, and right ventricular involvement. Purpose: To identify the baseline characteristics between two groups of patients with PPCM; patients with LVEF recovery within first year after diagnosis and patients who died within the same period after diagnosis. Also to identify the specific outcomes of the two groups. Methods: Retrospectively data were analyzed including patients with PPCM who had LVEF recovery within first year of diagnosis versus patients who died within one year after diagnosis. Data collected at cardio-obstetric clinic between January 2015 - November 2020. Results: Total number of patients who died within the first years were six patients while the total number of patients who had LVEF recovery within 1 year was 14 patients. Their clinical characteristics and outcomes are shown in table 1. Conclusions: Mortality group had less hypertension co-morbid disease, lower baseline systolic blood pressure, higher heart rate, lower LVEF, more right ventricular dysfunction, and less to be diagnosed in the postpartum period compared with LVEF recovered group. Use of spironolactone and bromocriptine were limited among both groups and light should be focus on this gap to be bridged. Lower rate of ACE-inhibitor use among mortality group may be explained by lower systolic blood pressure in this cohort. Most of the patients had LVEF recovery within the first 6-month and most of the patients in the other group died within the same period with sudden cardiac death as the leading cause of mortality.