Abstract
Abstract Biomarker development in the clinical trial setting is frequently limited by the availability of small tissue specimens, such as core needle biopsies. To enable forward and reverse translational assays to best understand patient-specified biomarkers, high-plex assays which can be performed on individual slides are critical. We’ve developed the GeoMx® Digital Spatial Profiler (DSP) and CosMx™ Spatial Molecular Imager (SMI) to allow researchers to explore more hypotheses simultaneously from standard histopathology slides. We demonstrate on standard FFPE sections how the GeoMx and CosMx platforms integrate within the context of biomarker discovery. The GeoMx platform can resolve transcriptome-wide RNA expression profiles or 150+ protein targets from tissue structures selected by pathological review. The CosMx platform allows subcellular profiling of up to 1000 RNA transcripts or 64 proteins from a single slide. We demonstrate the integration of GeoMx and CosMx into a multi-modal approach to how high-plex spatial platforms can complement conventional diagnostic assays for translational research. This includes integration with downstream analytical tools such as digital pathology suites as well as machine learning approaches to model patient outcomes. Spatial technologies, such as GeoMx and CosMx, present groundbreaking opportunities for improving accuracy in biomarker discovery and for providing rich biological insight beyond low-plex profiling approaches. Citation Format: Jason W. Reeves, Esperanza Anguiano, Vikram Devgan, Nicholas Confuorto, Joachim Schmid, Yan Liang, Joseph Beechem. An innovative spatial biology biomarker discovery approach to enable acceleration of drug development [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 985.
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