Abstract 9746: Atrial Fibrillation Among the Elderly With Amyloidosis Admitted for Acute Ischemic Stroke in the United States

Abstract

Introduction: Amyloidosis can disrupt several tissues, including the heart, causing various cardiac arrhythmias. Factors influencing the presence of Atrial Fibrillation in the elderly with amyloidosis admitted for Acute Ischemic Stroke (AIS) have been sparsely studied. Methods: Elderly patients of ages 60 and more with a diagnosis of amyloidosis and a principal diagnosis of Acute Ischemic Stroke (I63.x) were filtered from the 2019 National Inpatient Sample (NIS). All forms of Atrial Fibrillation and multiple risk factors were also identified via their appropriate codes provided by HCUP and based on recommendations from past studies. Results: Our analysis found 1570 elderly amyloidosis patients admitted for AIS in 2019. Among them, 490 cases (31.2%) also had a diagnosis of Atrial Fibrillation. Predictors of atrial fibrillation included hypertension (aOR 1.543, p=0.024), chronic pulmonary disease (aOR 1.541, p<0.01), use of intravenous tissue plasminogen activator (aOR 2.062, p<0.01), old CABG (aOR 3.350, p<0.01), current anticoagulation therapy (aOR 13.426, p<0.01), supraventricular tachycardia (aOR 3.970, p<0.01). Smoking (aOR 0.680, p<0.01), diabetes (aOR 0.597, p<0.01), and ventricular tachycardia (aOR 0.504, p= 0.033) showed lower risks. While a higher mortality rate was seen among patients with Atrial Fibrillation (30 deaths, 6.1% in Atrial Fibrillation vs. 4.6% in others), the result was not statistically significant (p=0.213). Patients with Atrial Fibrillation were also older (80.35 vs. 76.11 years) but had a shorter stay (6.22 vs. 6.81 days) with a lower mean hospital charge ($77,977.01 vs. $78,940.89). Conclusions: While various factors can influence the odds of Atrial Fibrillation in the elderly with amyloidosis admitted for acute ischemic stroke, it did not increase mortality risk.