Abstract 94: Mammographic Density in Middle to Low Breast Cancer Incidence Settings: DDM-Colombia

Abstract

Abstract Purpose: Mammographic density (MD) is a potential risk factor for breast cancer, which could be key to monitor prevention strategies and to detect high risk population. MD has been widely studied in high income countries; but not in countries of lower income levels. The aim of this study was to explore the determinants of MD among Colombian women (DDM-Colombia). Methods: Cross sectional study in women aged 40-72 years recruited consecutively in a private BC screening unit in Bogotá-Colombia, 2019-2020. Personal history and anthropometric measures were collected the same day that patients went to their mammogram exams. The study was approved by Fundación Sanitas' IRB. All patients agreed to join the study and signed the informed consent. A trained researcher estimated the percentage of MD using a validated semiautomatic computer tool (DM-scan). The differences in MD by menopausal status were analysed in a linear regression model adjusted by age, body mass index (BMI) and reproductive factors. Results: Preliminary results show the characteristics of 687 women (75 Premenopausal, 612 peri/postmenopausal). The mean age of the participants was 58 years (standard deviation (SD): 6.2) and the mean BMI was 27.6 (SD: 4.4). The overall percentage of MD was 25.3 (95% Confidence Interval (CI): 24.3 to 26.4); the percentage of MD in peri/postmenopausal was 9.6 points lower (CI: 6.3%-12.9) compare to premenopausal women. Conclusions: High MD prevalence is less common in Colombian women compared to high income countries. It is necessary to continue studying MD prevalence and determinants in this population, to assess the need to develop different prevention strategies for them. Funding: Ministerio de Ciencia Tecnología e Innovación Colombiano 122280764284 (771-2018). Citation Format: Ana Pedraza-Flechas, Sandra Gaitan, Kelly Estrada, Julian Camargo, Adriana Castillo, Tania Gonzalez, Martha Gonzalez, Ángela Pinzón-Rondon, Ángela Ruíz-Sternberg, Marina Pollán, Beatriz Perez-Gómez. Mammographic Density in Middle to Low Breast Cancer Incidence Settings: DDM-Colombia [abstract]. In: Proceedings of the 9th Annual Symposium on Global Cancer Research; Global Cancer Research and Control: Looking Back and Charting a Path Forward; 2021 Mar 10-11. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2021;30(7 Suppl):Abstract nr 94.