Abstract 9354: Socioeconomic, Demographic, and Geographic Trends in Mortality from Peripheral Artery Disease in the United States from 2000-2019

Abstract

Background: Much is known about mortality trends in coronary artery disease (CAD) and cerebrovascular disease (CVD), yet data reporting mortality trends for peripheral artery disease (PAD) are scarce. We sought to explore overall PAD mortality trends in the US. Methods: The Multiple Cause of Death database from the Center for Disease Control was used to identify patients, aged 25 years and older, who died of PAD between years 2000 to 2019. Patients who died from PAD were identified using International Classification of Diseases 10th revision codes. Patient socioeconomic, demographic, and geographic factors were reported and analyzed. Age-adjusted rate were calculated using a standard population and reported in per-million persons (PMP). Finally, PAD mortality trends were compared to CAD and CVD. Results: A total of 854,616 PAD deaths were identified and showed decreasing mortality from 403 to 99 age-adjusted years PMP from 2000-2019. PAD mortality increased with increasing age (crude rate of 1.0 PMP vs 3806 PMP among 25-34 vs >85 year-olds respectively). PAD mortality was also higher among Black individuals from 2000 to 2006, but has equalized to the mortality rate of White individuals. PAD mortality was higher among men compared to women, but the gap has decreased over time. There was significant geographic state-level variation (3 fold) in PAD mortality, with large fringe metros demonstrating the lowest mortality. When compared to CAD and CVD, PAD mortality decreased by 75% from 2000 and 2019, compared with a 61% reduction in CAD mortality and a 46% reduction in CVD mortality (Figure 1). Conclusion: From 2000 to 2019, mortality due to PAD in the US has decreased at a much higher rate compared to CAD and CVD. Despite this trend, PAD remains a major cause of mortality in the US, disproportionately affecting elderly individuals, generally those living in less metropolitan areas, and men of both White and Black ethnicity, although differences in race and gender are diminishing.