Abstract
Abstract Objective: In order to investigate possible genetic contribution to childhood leukemia in the immune system, we evaluated the associations between 786 SNPs in 68 genes/gene regions related to immune response and childhood leukemia risk. Methods: Incident childhood leukemia cases (n=136) and non-cancer controls (n=254) were recruited from three teaching hospitals in Seoul between 2003 and 2006. Candidate genes/gene regions were selected based on SNP databases (CGAP and SNP500 database), and genotype assay was performed using GoldenGate (Illumina) oligonucleotide pool assay (OPA). First, we selected SNPs with dose response effect (Ptrend<0.001). The 16 SNPs deemed unusable due to failure of genotyping or monomorphism (9 SNPs), low yield (2 SNPs), HWE p <0.001 (5 SNPs) in each case and control were excluded from the analysis. A gene-level minP was computed using a permutation-based re-sampling procedure (10,000 permutations) taking all SNPs in each gene/gene region into account. We considered minP <0.05 as noteworthy. Childhood leukemia risk was estimated as odds ratios (ORs) and 95% confidence intervals (CIs) adjusted for age, gender and birth weight. Results: Among the 786 SNPs, 134 SNPs in 7 genes/gene regions were significantly associated with childhood leukemia risk (Ptrend <0.001). Five out of 7 genes/gene regions of immune response (MDM2 (murine double minute 2), CD81 (CD81 molecule), IL-2 (interleukin 2), TNF/LTA (tumor necrosis factor-a (TNF) and lymphotoxin-a), RELB (v-rel reticuloendotheliosis viral oncogene homolog B)) were significantly associated with childhood leukemia risk (minP <0.01). Discussion: Our results suggest that genetic polymorphisms in immune regulatory may play a role in childhood leukemia development. Further large study is warranted confirm our findings. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 925.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
