Abstract 89: Translation and Linguistic Validation of the Mastectomy Module of the BREAST-Q Questionnaire for Use in Nigeria

Abstract

Abstract Purpose: The majority of breast cancer patients in sub-Saharan Africa are recommended to have mastectomy; The impact of mastectomy on a predominantly young African patient population requires evaluation. The BREAST-Q is a validated patient-reported outcome measure of quality-of-life following breast surgery that has been translated into 30 languages-none in Africa. This study aimed to translate and validate the mastectomy module of the BREAST-Q for use in Nigeria. Methods: The BREAST-Q mastectomy module was translated from English to Yoruba (a major Nigerian language) and linguistically validated using best practice guidelines. Translation was performed in 4 steps: forward translation (x 2), back translation, back translation review, and cognitive interviews with post-mastectomy patients. The translated BREAST-Q instrument was administered to post-mastectomy patients (n=21) alongside the EORTC-QLQ BR23 to evaluate construct validity. Results: The translation process identified phrases not amenable to direct translation, including “emotionally healthy” and descriptions of pain (“nagging,” “throbbing,” “sharp”). Translations were amended to reflect local context and question intent. Patients provided suggestions to simplify complex phrases, such as “discomfort in your breast area.”during cognitive interviews. Internal consistency within scales was over the 0.70 threshold for psychosocial wellbeing (α=0.84-0.87), sexual wellbeing (α =0.98-0.99), physical wellbeing in chest (α =0.84-0.86), and satisfaction with care (α =0.89-0.93). ICC for test-retest reliability was moderate (0.46-0.63). Conclusion: The Yoruba version of the BREAST-Q mastectomy module in Yoruba presents a conceptually equivalent version in a language that is easy to understand.. We will use this validated instrument in a pilot study of Nigerian patients to identify targets for intervention to improve the patient experience and compliance with breast cancer surgery. Citation Format: Olalekan Olasehinde, Anya Romanoff. Translation and Linguistic Validation of the Mastectomy Module of the BREAST-Q Questionnaire for Use in Nigeria [abstract]. In: Proceedings of the 11th Annual Symposium on Global Cancer Research; Closing the Research-to-Implementation Gap; 2023 Apr 4-6. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2023;32(6_Suppl):Abstract nr 89.