ABSTRACT 885

Abstract

Background and aims: To explore the relationship between blood lactate level and disease severity as well as prognosis in children with septic shock. Aims: To explore the relationship between blood lactate level and disease severity as well as prognosis in children with septic shock. Methods: From July 1, 2010 to June 30, 2012, 107 children with septic shock were treated in our pediatric intensive care unit (PICU), the clinical data were retrospectively collected and analyzed. Patients were divided into three groups on the basis of blood lactate level: normal lactate level (n=32), hyperlactatemia (n=31) and lactic acidosis (n=41). The percentage of compensated disease, pediatric critical illness score (PCIS), and prognosis were compared between three groups. Results: The percentage of patients with decompensated septic shock differed significantly between three groups (P<0.01). For patients with compensated septic shock, PCIS was significantly different between three groups (P <0.05). The same result was observed in patients with decompensated septic shock. The Spearman correlational analysis revealed an evident negative correlation between blood lactate level and PCIS (P=0.001). For patients with compensated septic shock, the cure and improvement rates in normal lactate level group (21.8% and 31.2%, respectively), and hyperlactatemia group (22.5% and 38.7%,respectively) were significantly higher than in the lactic acidosis group (0% and 12.2%, respectively). For patients with decompensated septic shock,, the mortality in lactic acidosis group (29.3%) was observably higher than in the normal lactate level group (0%), and hyperlactatemia group (9.7%), P<0.05. Conclusions: The blood lactate level correlated well with disease severity and prognosis in patients with septic shock.