ABSTRACT 873

Abstract

Background and aims: We had a ten consecutive years monitoring and clinical research to find the pathogenic bacteria distribution and drug resistance in children with sepsis. Aims: To find the pathogenic bacteria distribution and drug resistance in children with sepsis . Methods: The patients with sepsis in our hospital from 2002 to 2011 who had positive blood culture were enrolled in our study ;A statistical analysis about the pathogenic bacteria distribution and drug resistance and clinical summary had done. Results: 2493 (3.64%)strains of pathogenic bacteria were detected in 68419 specimens of blood culture, the most common pathogenic bacteria were gram-positive cocci, the top five pathogenic bacteria were coagulase negative staphylococcus (CNS), Escherichia coli, the fermentation bacteria, enterococcus, salmonella. Comparison between the first five years and the late five years : CNS, klebsiella, Alcaligenes Castellani and fungi were obviously more in the late five years; Staphylococcus aureus, enterococcus, fPseudomonas, salmonella decreased significantly. The most common pathogenic bacteria in neonatal and children were different. drug resistance increased in the late five years, Gram-positive bacterium is highly resistant to penicillin and erythromycin, we found no vancomycin resistant strains. E. coli with ESBLs positive strains were highly resistant to antibiotics; Klebsiella Trevisan resistant rate increased year by year. There were no Imipenem resistant strains; Conclusions: Coagulase negative staphylococcus was the most common pathogenic bacteria in children with sepsis in the last 10 years, drug resitance were increased and multiple drug resistant organisms were found.