Abstract
To clarify the efficacy of soy at reducing visceral fat, we planned a randomized, double-blind, controlled, comparative trial that compared formula food containing soy bean protein (SP) to the same food in which soy was replaced by milk protein (MP). Forty-eight participants were enrolled for the treatment of visceral fat obesity: visceral fat area greater than 100cm 2 as calculated by CT. The SP formula contained 12g of soy bean protein, 9g of milk protein, and other nutrients, and was administered for 20 weeks in the morning, while in the MP formula soy bean protein was replaced by milk protein. During the 20 weeks of the trial period, visceral fat area and subcutaneous fat area in MP group were significantly reduced, while those in SP group did not change as assessed by an analysis of covariance. While waist circumference was reduced in both SP and MP groups, BW and BMI were significantly reduced only in MP group. Based on a mixed-effects model, the difference in log-transformed visceral fat profiles between the two groups was statistically significant (p<0.05), while a negative relationship was observed between the changes in visceral fat and adiponectin in the MP group (p<0.001), but not in SP group. In conclusion, formula containing milk protein is superior to that containing soy bean protein for reducing visceral and subcutaneous fat.
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