Abstract 806: Mitochondrial oncobioenergetic Index (MOBI) mediated by oxidative stress as a marker for progression from indolent to aggressive cancer

Abstract

Abstract Cellular Metabolic profile is governed by the way which the mitochondria functions in a cell. Any change in mitochondrial function would alter the cellular metabolic profile. During the evolution of tumor from onset to aggressive cancer, the metabolic needs also differs as alterations in oncogenes, tumor suppressor genes, and changes in the epigenetics and microenvironment occurs at each stage of the tumorigenesis process. Therefore, we hypothesized that mitochondrial function will be stably and dynamically altered at each stage of the tumor development. Moreover, the ability mitochondria to withstand stress will also be different. We recently defined MOBI, which is a mathematical representation of oncobioenergetic profile of a cancer cell. MOBI increases significantly upon transformation into localized premalignant form and rapidly falls below the normal as they become aggressive. We also show that the MOBI of cancer cells at various stages of tumorigenesis after oxidative stress depend on their initial MOBI. Aggressive cancer cells completely lost their MOBI upon stress, even though some of the cancer cells had high initial reserve capacity. However, cells from pre-malignant cells had significantly higher MOBI than the normal epithelial cells. This study thus reveals that MOBI could be a potential biomarker to distinguish aggressive cancer from that of indolent disease and screening of compounds that specifically target the bioenergetics of cancer cells. Citation Format: Praveen Kumar Vayalil. Mitochondrial oncobioenergetic Index (MOBI) mediated by oxidative stress as a marker for progression from indolent to aggressive cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 806.