Abstract 767: The role of abdominal obesity in the association between obesity and prostate cancer: A U.S. population-based cross-sectional study NHANES 2001-2020

Abstract

Abstract Background: Research suggests inconsistent evidence regarding the association between general obesity and prostate cancer among men in the United States. This study aimed to examine whether the association between general obesity and prostate cancer is influenced by abdominal obesity. Methods: This study utilized data from the National Health and Nutrition Examination Survey (NHANES), 2001-2020, a nationally representative survey. The analysis was restricted to 16,703 non-Hispanic men (10,683 White and 6,020 Black). General obesity was defined by a body mass index of 30 kg/m2 or greater and abdominal obesity was defined by a waist circumference of 102 cm or greater. Respondents were classified into four mutually exclusive groups according to the body fat indicators: 1) presence of both general and abdominal obesity, 2) abdominal obesity without general obesity, 3) general obesity without abdominal obesity, and 4) none of the two (the reference group). Results: The overall prevalence of prostate cancer was 2.25% (95% CI: 2.0-2.5%). Men with abdominal obesity without general obesity have significantly higher prevalence of prostate cancer (4.28%) compared to men with both abdominal obesity and general obesity (2.23%), men with neither abdominal obesity or general obesity (1.70%), and men with general obesity without abdominal obesity (0.18%), P <.0001. Black men with abdominal obesity without general obesity have the highest prevalence of prostate cancer (7.21%), followed by White men with abdominal obesity without general obesity (4.10%). With and without adjusting for age and education, men with abdominal obesity without general obesity had significantly higher odds of prostate cancer, regardless of ethnicity. Black men with both abdominal obesity and general obesity had significantly higher odds of prostate cancer. General obesity without abdominal obesity was inversely associated with prostate cancer in White men but not in Black men. Conclusions: This study illustrates that waist circumference is a potential classifier of prostate cancer as it shows variation in prevalence of prostate cancer by general obesity within the same and different racial and ethnic groups. Citation Format: Anwar E. Ahmed, Callista B. Martin, Bassam Dahman, Sean Q. Kern, Gregory T. Chesnut. The role of abdominal obesity in the association between obesity and prostate cancer: A U.S. population-based cross-sectional study NHANES 2001-2020 [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 767.