Abstract 7640: Prognostic significance of S100A16 expression in patients with resected lung adenocarcinoma

Abstract

Abstract Background: Lung cancer is the leading cause of cancer death worldwide. Tumor recurrence is the most common cause of treatment failure after surgical resection. The S100 protein family is a multigenic group of cytoplasmic calcium-binding proteins. S100A16 has to be reported to be an independent prognostic indicator of poor overall survival in lung adenocarcinoma recently. However, the prognostic value of S100A16 in recurrence-free survival (RFS) in patients with resected lung adenocarcinoma has not been well demonstrated. The relationship between S100A16 expression and the histological subtypes of lung adenocarcinoma remained unknown. Methods: A total of 79 patients with resected lung adenocarcinoma were included in the study. S100A16 expression was determined by immunohistochemistry in tumor specimens. The prognostic value of S100A16 overexpression and its relationship with clinicopathological variables, including histology subtypes, were investigated. Results: S100A16 overexpression tended to be significantly associated with order age (P = 0.074). There was no significant association between S100A16 overexpression and predominant pattern group (lepidic/acinar/papillary vs. micropapillary/solid) (P = 0.447). Univariate analysis indicated that pathologic stage (II or III vs. I) (P = 0.001) and S100A16 overexpression (P = 0.005) were significant prognostic factors for worse recurrence-free survival (RFS). Predominant pattern group (lepidic/acinar/papillary vs. micropapillary/solid) (P = 0.064) tended to be a significant prognostic factor for worse RFS. In multivariate analysis, pathologic stage (II or III vs. I) (HR, 27.847; 95% CI, 4.173 to 185.831; P = 0.001), and S100A16 overexpression (HR, 21.740; 95% CI, 2.516 to 187.870; P = 0.005) were still significant prognostic factors for worse RFS. Conclusions: S100A16 overexpression was a significant prognostic factor for worse RFS in patients with resected lung adenocarcinoma. This information is useful to stratify high-risk patients of recurrence after resection of lung adenocarcinoma. Citation Format: Jung-Jyh Hung. Prognostic significance of S100A16 expression in patients with resected lung adenocarcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 7640.