Abstract 733: Adolescent dietary patterns in relation to later prostate cancer risk and mortality in the NIH-AARP diet and health study

Abstract

Abstract Background: Although adolescent diet has been proposed to contribute to prostate cancer (PCa) development, no studies have investigated the relation between adolescent dietary patterns and PCa risk or mortality. Method: Using data from the NIH-AARP Diet and Health Study, we performed factor analysis to identify dietary patterns at ages 12-13 years. We further used Cox proportional hazards regression to examine hazard ratios (HRs) and 95% confidence intervals (CIs) of total, non-advanced, advanced, and fatal PCa. Results: During 1,878,681 person-years of follow-up, 17,861 men were diagnosed with PCa, including 15,499 non-advanced, 2,362 advanced, and 832 fatal cancers. Three adolescent dietary patterns were identified: a Western modern pattern characterized by greater intake of sweets, processed meat, beef, cheese, and pizza; a plant-based pattern characterized by greater intake of vegetables, fruits, and dark bread; and a Western traditional pattern characterized by greater intake of gravy, bacon, and chicken, eggs, potatoes, green beans, legumes, and white bread. Although not entirely consistent across analyses, a higher adolescent plant-based pattern score was associated with reduced risks of total PCa (fully-adjusted HRQ5vs.Q1=0.93, 95% CI: 0.89-0.98, p-trend=0.003) and non-advanced PCa (HR=0.91, 95% CI: 0.87-0.96, p-trend<0.001), whereas no associations were observed for Western modern or Western traditional patterns. Conclusions: In the first study, to our knowledge, to investigate adolescent dietary patterns and PCa risk, we found some evidence to support a protective role for a plant-based diet during adolescence on PCa risk. Our findings may inform the development of new, primary prevention strategies for PCa. Citation Format: Tuo Lan, Yikyung Park, Graham A. Colditz, Jingxia Liu, Molin Wang, Kana Wu, Edward Giovannucci, Siobhan Sutcliffe. Adolescent dietary patterns in relation to later prostate cancer risk and mortality in the NIH-AARP diet and health study [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 733.