Abstract 7328: Relationship between PIN3 16bp duplication of TP53 and HPV in HIV women in Mali

Abstract

Abstract Background: TP53 polymorphisms can influence the immune response to HPV, affecting TP53's role in cell cycle regulation and apoptosis, crucial for controlling HPV infection and preventing cancer. Objective: Explore the link between TP53 PIN3 16-bp duplication and HPV infection in HIV-positive Malian women. Methods: This study explored the link between PIN3 16-bp duplication polymorphism of TP53 and HPV infection in 50 HIV-positive women in Mali. Data included surveys, self-sampled vaginal swabs, and blood collection. HPV typing used GeneXpert, and PIN3 genotyping utilized AS-PCR. Results: Participants, primarily >30 years (92%), had a mean age of 43.30 ± 10.332 years. HPV prevalence was 36%, with P3 being the most common subtype (30.8%). PIN3 genotypic frequencies were A1A1 (50%), A1A2 (34%), and A2A2 (10%). History of sexually transmitted infections correlated with higher mutation rates (37.8% A1A2, 10.8% A2A2). A2A2 genotype prevalence was higher in HIV-positive women with specific HPV subtypes (P5, P4, HPV16, P3, P18/45). A1A2 genotype was observed in 60% of HPV subtype P3 cases and 20% of P4 and P18/45 cases. Conclusion: These results suggest a link between TP53 gene polymorphisms and susceptibility to different HPV subtypes in HIV-positive women, warranting further research into their functional implications and impact on HPV-related diseases in this population. Keywords: TP53 polymorphism, HPV, HIV, Malian population Citation Format: Mamoudou Maiga, Brehima Diakite, Yaya Kassogue, Ban Traore, Oumar Kassogue, Bakarou Kamate, Cheick B. Traore, Jane L. Holl, Lifang Hou. Relationship between PIN3 16bp duplication of TP53 and HPV in HIV women in Mali [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 7328.