Abstract 672: Baseline serum albumin as a prognostic factor in patients with stage I and II colon adenocarcinoma

Abstract

Abstract Background: Patients with stage I or II colon carcinoma (CC) have a significant risk of recurrence after adequately performed curative resection. Adjuvant chemotherapy has not improved recurrence or survival in such patients. In this study, a prognostic model in patients with stage I or II CC is presented. Methods: Consecutive cases with CC treated at a cancer center in Mexico City from January 2008 to December 2014, with diagnosis of adenocarcinoma by colonoscopy and biopsy were included in this cohort. Patients were treated according to standard guidelines. Follow-up continued until June 2016; the Kaplan-Meier method and the Cox model were used to analyze the association of prognostic factors and overall survival (OS). Results: 1,259 cases of CC were treated; only 496 patients have stage I and II CC and were included in the database: 234 women (47.2%) and 262 males (52.8%) and their mean age was 59.9 years (SD 14.9); 96, 339, 31 and 30 cases were pTNM stages I, IIa, IIb and IIc, respectively. Multivariate analysis of prognostic factors is depicted below. Predicted survival functions using this model, defined 4 risk groups that showed better prognostic value than simple TNM stages I-IIc. Conlusion: BSA is an independent, significant, simple, cheap and widely available prognostic factor in patients with CC. BSA and other clinical factors add significant prognostic information to TNM classification. Feasibly, it can be used to develop multivariate prognostic models with clinical impact defining the use of adjuvant chemotherapy. The use of histopathological and immunohistochemical markers could improve the prognostic information of this model. Multivariate análisis of prognostic factorsBetaSEpHR95% CIMale gender0.3550.1660.0321.4261.031-1.973Hemoglobin-0.0880.0380.020.9160.85-0.986Platelet count-0.0020.0010.0010.9980.996-0.999Neutrophil count0.0820.0280.0041.0851.027-1.147Albumin0.7820.2280.0012.1851.397-3.417Albumin/Globulin-1.6240.4880.0010.1970.076-0.513BMI-0.0420.0220.0510.9580.918-1.0TNM 0/I0.0541TNM IIa0.5540.2550.031.741.056-2.869TNM Iib0.7340.4040.0692.0830.944-4.597TNM IIc0.950.3670.012.5861.26-5.305Chemotherapy-0.7650.2<0.00010.4650.315-0.688R0<0.00011R10.2670.4750.5741.3060.515-3.311R20.9360.3480.0072.5511.29-5.044No Resection1.9360.288<0.00016.9323.944-12.18Platelet/Lymphocute ratio0.0010.0010.081.0011.0-1.002 Citation Format: Luis F. Onate-Ocana. Baseline serum albumin as a prognostic factor in patients with stage I and II colon adenocarcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 672. doi:10.1158/1538-7445.AM2017-672