ABSTRACT 658

Abstract

Background and aims: Fetal growth restriction (FGR) is due to various pathological factors that causes fetal growth restricted, failed to play the best growth potential. However, despite being the largest developing country, China still lacks general data on FGR. Aims: To investigate the incidence and risk factors of FGR in Mainland China and its adverse influence on fetal-neonatal health. Methods: This work was approved by our hospital ethic committee. (1) The prevalence of FGR: the clinic data of maternal and newborn infants from six hospitals in Mainland Chia were retrospectively analysed. (2) The near-term outcomes of FGR: the data come from Bayi Children’s Hospital were analysed.The long-term outcomes of FGR: a follow-up study of 125 cases FGR child at 18 months of life. (3) The physical development index, MDI, PDI were observed between two groups. Results: (1) The incidence rate of FGR was 8.8%.The FGR incidence in females was 9.8% and it was 7.84% in males,in preterm infants (16.4%) was higher than that of term infants(7.9%)(P<0.01).(2) Logistic analysis showed that hypertensive, abnormal amniotic fluid, and abnormality of umbilical cord were independent factors of FGR. (3) There were significantly higher incidences of complications in FGR infants. FGR prolonged their duration of hospital stay and increased their hospitalization expenses markedly (p<0.05). (4) FGR child physical development has catch-up growth and can reach the level of normal control groups at 1.5-year, but still remain lower score both MDI and PDI. Conclusions: The incidence of FGR is as high as 8.8% in Mainland China, it has adverse influence on fetal-neonatal health and cognitive development.This work was supported by Natural Science Foundation of China (81170577).