ABSTRACT 644

Abstract

Background and aims: Triple lumen central venous catheters (CVC) are a common source of catheter-associated bloodstream infection (CABSI) in our 22-bed tertiary PICU. Aims: To assess the relationship between triple lumen CVC dwelling time and CABSI causative microorganism. Methods: Prospective clinical and laboratory data on all PICU admissions for 24 months (3/2010–3/2012), missing data was supplemented retrospectively using electronic patient records. The UK National Patient Safety Association ‘Matching Michigan’ case definitions were utilized to identify bloodstream infections and CABSI. The study was approved by the Clinical Audit Department- a division of the Directorate of Research and Clinical Development at Alder Hey Children’s Hospital. Results: PICU-acquired CABSI rate was 7.35 per 1000 central line days. Device utilization ratio (CVC days per patient days) was 0.77. Triple lumen CVC was the source of the CABSI in 27 cases (44%).Table 1: PICU blood cultures dataTable 2: Clinical characteristics of triple lumen CVC culturesConclusions: Enteral bacteria - Enterococcus and Enterobacter species may cause earlier CABSI onset than CONS and Candida (p=0.02).