Abstract
Background: The role of preventive cardiology becomes more significant in solving heart problems. The analysis of our research results allows making assumptions, promising for prevention of coronary atherosclerosis (CA). Material and Methods: The studies were carried out on: hearts of humans died from accidents, from acute myocardial infarction; myocardial biopsies, heart surgical material of patients; hearts of animals; insects flying muscles; placentas of human and animals. The methods were used: autopsy, planimetry of atherosclerotic lesions of aorta and main coronary arteries, heart biopsy, microangio-x-ray, histology, stereology, experimental modeling, measuring of hemodynamic parameters, micromechanography, electron microscopy, cytochemistry, mathematical modeling, statistics. Aim: To show that existing data may serve as a basis for further development of new ways to prevent CA. Results: Huge differences of myocardial arterial bed (MAB) density exist. The richness of MAB correlates directly with life expectancy of people. In hearts with scant MAB CA develops earlier and atherosclerotic lesions are more severe. Therefore scant MAB is considered as an intracardial risk factor (IRF) for IHD. Large individual differences exist in human hearts also for values for the duration of myocardial fibers oxygen supply. The long time is another IRF for IHD. The density of intraorganic arterial bed in human placentas varies widely. There is a positive correlation between placental arterialization density and newborn weigh. The following morphological multifactorial systemic measurement methods are developed: a) for heart muscle oxygen supply; b) for contractility of cardiomyocyte using small heart muscle biopsies (patented); c) for gas exchangeability of placenta. The efficiency and exactness of each method were examined. Conclusion: The received data allow assuming that atherosclerotic profile of human heart CA will be possible to foretell on the next day of born. In cases of bad prognosis a plan of enrichment of MAB, a plan for spatial improvement of the “capillary - myocardial fiber” system may be composed and undertaken. The received data allow in advanced future to draw up a project of new heart with necessary preset structural parameters.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Arteriosclerosis, Thrombosis, and Vascular Biology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
