ABSTRACT 641

Abstract

Background and aims: Neonatal purulent meningitis is common and can result severe sequelae. Aims: To explore the clinical characteristics and treatment method of neonatal purulent meningitis. Methods: Totally hospitalized patients with neonatal purulent meningitis were enrolled during January 1 2011 to December 31 2012 in Hunan Children’s Hospital. Total 172 cases were retrospectively analyzed. Results: The starting clinical symptoms of neonatal purulent meningitis are fever, convulsions. The colour of cerebrospinal fluid is normal in 119 cases (69.2%). Leukocyte of CSF is increased in 164 cases (95.3%).Protein is elevatory in 95 cases (55.2%). Sugar of cerebrospinal fluid is depressed in 88 cases (51.2%). Culture of cerebrospinal fluid is positive only in 40 cases (23.3%). Complications occurred in 31 cases (18%), and 14 cases were hydrocephalus (8.1%). Compared with other fester sex meningitis, fever last time in E. coli meningitis group was no significant difference (P>0.05), time need for cerebrospinal fluid dropping to normal was much longer (p<0.05). For abnormal color of CSF, increasing of leukocyte, protein, reducing of sugar, incidence of complications, length of hospital stay, hospital expenses, there was significant difference in two groups. Conclusions: Starting symptoms of neonatal purulent meningitis is fever. Once the fever lasts for more than 24–72 hours, it is recommended to check lumbar puncture routinely. For, treatment time is long, rate of complications and fatality is high. Most of E. coli meningitis have sequelae.