Abstract 637: A prospective study of tea and coffee intake and risk of glioma

Abstract

Abstract Background: Tea and coffee have anti-inflammatory, anti-oxidant and neuroprotective effects mediated by a variety of compounds, including polyphenols. Observational studies suggest that tea and coffee intake may reduce risk of certain cancers, although the data on glioma risk are limited and inconclusive. Methods: We evaluated the association between tea, coffee, and caffeine intake and risk of glioma in the female Nurses’ Health Study (NHS, n=92,389, followed 33 years) and Nurses’ Health Study II (NHSII, n=95,242, followed 23 years) and the male Health Professionals Follow-up Study (HPFS, n=49,885, followed 29 years). Cumulatively updated tea and coffee intake were derived from validated quadrennial food frequency questionnaires. Glioma cases were confirmed by medical record review. Age-adjusted hazard ratios of glioma by category of beverage intake were estimated using Cox proportional hazards models. Associations across the combined cohorts were calculated using fixed effect meta-analysis. Results: We documented 554 incident cases of glioma, including 256 in NHS, 87 in NHSII, and 211 in HPFS (159, 52, 151 glioblastomas, respectively). Compared to <1 cup/week, higher tea consumption was inversely associated with glioma risk in women (HR=0.65, 95% CI 0.41-1.03 for >2 cups/day, p-trend=0.03), and was inversely, but not significantly, associated in men (HR=0.70, 95%CI 0.30-1.61 for >2 cups/day, p-trend=0.30). In women and men combined, the corresponding HR was 0.66 (95% CI 0.44-0.99) for >2 cups/day (p-trend=0.02). We observed no significant associations between caffeinated, decaffeinated, or total coffee intake and glioma risk in men or women. We found no material differences in the results when baseline values were used, when responses were lagged by eight years, or when cases were limited to glioblastoma only. Conclusion: In three large, prospective cohort studies of men and women, tea intake was inversely associated with glioma risk, particularly in women. No significant associations were observed for coffee intake of any type and glioma risk. These results merit further exploration in other prospective studies. Note: This abstract was not presented at the meeting. Citation Format: David J. Cote, Alaina M. Bever, Kathryn M. Wilson, Timothy R. Smith, Stephanie A. Smith-Warner, Meir Stampfer. A prospective study of tea and coffee intake and risk of glioma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 637.