Abstract 6207: Exploring colorectal cancer with ARIA: Biomedical insights

Abstract

Abstract Gaining the promised benefits from the population-scale datasets, both clinical and genomic, is often hindered by the inability to easily access, explore and manipulate such complex data - a difficulty that ARIA was designed to overcome. In the field of biomedicine, organizations harness extensive datasets, gaining profound insights into patients and participants, thereby unleashing possibilities for accelerating research, especially in the realms of drug development and precision medicine. To facilitate navigation through the intricate landscape of biomedical data, Velsera has innovated ARIA to catalyse efficient and insightful analysis, with a keen emphasis on user-friendliness to ensure accessibility across a diverse professional audience. To demonstrate the practical application of ARIA, we explore genomic and clinical datasets to identify key differences in colorectal cancer progression. CRC, the third most common cancer globally, has unique characteristics in origination and progression from benign to pathogenic. Here we investigate differences between patients with polyps that do and do not progress to CRC, including key environmental factors such as smoking history, inactive lifestyle and obesity in conjunction with their known clinical and genetic risk factors. This exploration into the abilities of ARIA demonstrate the ability to analyse complex datasets combining both clinical and genomics data at a large scale. For the purpose of this demonstration, a Synthea Dataset, encompassing synthetic clinical and genomic data for 122,011 patients across various age groups, was utilized. This dataset was generated by Velsera specifically for testing ARIA functionalities. In conclusion, ARIA empowers efficient analysis of complex biomedical datasets, providing a comprehensive understanding of disease mechanisms and facilitating valuable insights. Citation Format: Nevena Nikolic, Sarah Kleinstein, Jelena Radenkovic, Milan Kovacevic. Exploring colorectal cancer with ARIA: Biomedical insights [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 6207.