Abstract 620: Interrogating the molecular profile of lung cancer tumors in Puerto Rican Hispanics

Abstract

Abstract Background: In the United States, lung cancer accounted for approximately one-quarter of all cancer deaths; meanwhile, it was reported as the second cause of death in Puerto Rico (PR) for 2018. Worldwide, the development of new technologies such as next-generation sequencing (NGS) has allowed describing the profile of tumors and identifying mutation drivers in oncologic patients. The information on these is limited for Puerto Rican Hispanics (PRH). Methods: Using retrospective data from CARIS Life Sciences from 2015 to 2020, we were able to estimate the prevalence of somatic mutations of 119 PRH with lung cancer. In addition, we compared them with the mutational profiles reported for lung cancer from the TCGA Pan-Lung data available in the cBioPortal for Cancer Genomics. Frequencies and percentages were calculated to describe the data. Results: The results showed that the 10 most mutated genes for lung cancer tumors in PRH were TP53 (53.7%, n=67), EGFR (20.6%, n=73), KRAS (20.6%, n=73), T.M.L. (14.1%, n=64), APC (11.0, n=73), PTEN (10.3%, n=68), ARID1A (13.6%, n=44), PIK3CA (6.9%, n=73), STK11 (6.9%, n=72), and BRAF (5.5%, n=73). Additionally, only one positive mutation was found in MET (1.4%, n=72), and no mutations were identified in ALK and RET. When comparing to the top 10 tumor mutational profiles from the TCGA study, only BRAF was observed with a mutational frequency of 67.7% (n=1,444). Conclusion: Understanding the common molecular pathways that affect the PRH population is necessary to develop new therapeutic modalities. Moreover, this preliminary review of oncogenic drivers in PRH with lung cancer will inform clinicians, scientists, and the health community about actionable mutations to guide research, treatment, and health policy efforts. Citation Format: Hilmaris Centeno-Girona, Ingrid M. Montes-Rodríguez, Camila Rivera-Lynch, Marievelisse Soto-Salgado, Noridza Rivera, Marcia Cruz-Correa. Interrogating the molecular profile of lung cancer tumors in Puerto Rican Hispanics [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 620.