Abstract 616: Aging, Menopause And Metabolic Syndrome As Related To The Beneficial Effects Of Exercise Training

Abstract

Menopause and aging are associated with increased blood pressure. High fructose may modify the development of the pathologies associated with these conditions. The objective was to investigate the effects of exercise training (ET) in aged, oophorectomy mimic of menopause fructose-fed rats. Female Wistar rats (24 months old) were ovariectomized, fed with fructose (100g/L) in drinking water and divided in 5 groups (n=8/group): control (C), ovariectomized (O), ovariectomized trained (OT, n= 8), ovariectomized fructose (OF, n= 8) and ovariectomized fructose trained (OFT, n= 8). The ET was performed on a treadmill (1 h/day; 5 days/wk for 8 wk). The metabolic results showed that ET decreased adipose tissue in both trained groups (OT: 4.3±0.5, OFT: 5.3±0.7), compared with sedentary rats (C: 6.2± 0.6, O: 9.6±1.3, OF: 10.1±0.6, g). The same findings were observed for insulin resistance (OT: 4.6±0.2, OFT: 5.5±0.6 vs C: 3.2± 0.6, O: 3.2±0.3, OF: 4.0±0.5, mg/dl/min). ET increased physical capacity (OT: 20±0.9, OFT: 17.5±0.9 vs C: 11.5± 0.5, O: 10±0.5, OF: 10.3±0.5 Min/h). The hemodynamic results showed that ET attenuated the increase in MBP (C: 109.4± 1.9, OT: 103±1.1, OFT: 107±1.1 vs O: 119.1±1.9, OF: 119.1±2.7, mmHg) and HR (C: 341.4± 8, OT: 302±1, OFT: 306.4±8 vs O: 398.17±19, OF: 378.9±17 Bpm). The sympathetic tonus was decreased in C, OT and OTF (C: 63.6± 4, OT: 62.2±3, OFT: 51.2± 7 beats/ min) when compared with O and OF (O: 102.6±12, OF: 91.9±7 beats/min) while vagal tonus was increased just in OT (OT: 44.8±5) vs (C: 24.9± 6, OFT: 22±3, O: 13±6, OF: 9±2 beats/min). The OT and OTF groups showed an increased bradycardic response to BP changes (C: -1.50±0.06 OT: -1.74±0.12, OFT: -1.77±0.15 vs O: -0.93±0.07, OF: -1.21±0.12 bpm/mmHg). ET increased the Standard deviation of the pulse interval (C: 6.7±1.1 OT: 11.6±0.8, OFT: 13.0±1.5 vs O: 7.05±0.6, OF: 9.57±0.7 ms) and decreased VARR PAS (C: 6.7±1.09 OT: 23.6±0.8, OFT: 30.7±2.6 vs O: 56.4±8.1, OF: 40.5±3.7 mmHg2) as well as representative sympathetic modulation (LF PAS) (C: 6.7±1.1 OT: 3.6±0.5, OFT: 3.7±0.4 vs O: 9.8±1.2, OF: 8.3±0.8 mmHg. In conclusion, ET effectively improved metabolic and cardiovascular parameters altered by aged or excessive fructose consumption in rats submitted to ovarian hormone deprivation.