Abstract
Abstract In Taiwan, oral cancer (including sub-sites in the oral cavity, oropharynx and hypopharynx) is the fourth most common cancer in men. The incidence of oral cancer still increased in the past decade. Oxidative stress generated from cigarette smoking, AQ chewing and alcohol drinking was shown to contribute to oral cancer development. The oxidative stress associated DNA lesions are repaired via the DNA base excision repair (BER) pathway. In constrast, radiation therapy was an important treatment modality either as primary or adjuvant in these patients. Ionizing radiation induced DNA damage was also repaired by BER related mechanisms. To investigate the role of BER genes XRCC1 in patients receiving radiation therapy in Taiwan, a comprehensive study on evaluation of polymorphisms of XRCC1 genes was carried out in 753 oral cancer male cases received radiation therapy as primary or adjuvant treatment. Patients with XRCC1 194Arg, XRCC1 280Arg, and XRCC1399Gln homozygous genotypes had worse disease-free survival (p = 0.015, p = 0.587 and p = 0.013, respectively). A linkage disequilibrium exists between XRCC1 194Arg and XRCC1 399Gln genotyping. We further investigated the influence of XRCC1 194Arg and XRCC1 399Gln haplotype in the radiation effects in oral cancer patients. XRCC1 194 Arg/Arg homozygous and its combination with XRCC1 399 Arg/Gln genotyping were selected. We found that the XRCC1 194Arg/Arg and XRCC1 399Gln/Gln haplotype had the worse survival (p = 0.022, ). Multivariate Cox regression adjusting tumor stage, lymph node metastasis and tumor differentiation confirmed that XRCC1 194Arg and XRCC1 399Gln haplotype was an independent prognostic factor for oral cancer receiving radiation therapy. These indicated that XRCC1 194Arg and XRCC1 399Gln genotypes had adverse influence in oral cancer patients receiving radiation therapy. XRCC1 194Arg and XRCC1 399Gln haplotype predicts poor prognosis in these patients. Citation Format: Shiang-Fu Huang, Huei-Tzu Chien, Chun-Ta Liao, Hung-Ming Wang, Yuan-Hung Wang. Roles of XRCC1 genetic polymorphism in head and neck cancer patients receiving radiation therapy in Taiwan [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 615.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
