Abstract 581: Impact Of Iron Deficiency Anemia On Venous Thromboembolic Diseases: A National Inpatient Sample Analysis

Abstract

Introduction: Iron deficiency anemia has been associated with venous thromboembolic diseases however, there is paucity of data on the subject. We sought to assess this association using a national database. Methods: The National inpatient sample database 2018-2020 was queried to identify adult patients (age>18 yrs) with iron deficiency anemia (IDA). Baseline risk factors and occurrence of venous thromboembolic diseases were compared between patients with and without IDA. Multivariate regression analysis was performed to assess the impact of IDA on VTE. Results: A total of 6417659 patients with IDA were identified with a mean age of 61 years. Patients with IDA had a higher prevalence of diabetes mellitus, hyperlipidemia, tobacco abuse and obesity while they had a lower prevalence of hypertension. The occurrence of acute deep vein thrombosis (DVT), chronic DVT, acute pulmonary embolism (PE) and chronic PE was higher in patients with IDA than patients without (Table1). Multivariate regression analysis revealed a higher odds of developing acute DVT and acute PE in adult patients with IDA (Table 2). Conclusion: In sync with findings from a few other population studies, this analysis also reveals an association between IDA and VTE. Reactive thrombocytosis and elevated inflammatory markers have been proposed as few contributing factors. However, further research is warranted to prove these findings to aid prevent and treat VTE effectively.