Abstract 5662: Comparative Ablation Analysis in a Swine Intracardiac Model: Lesion Effectiveness of Ablation Within the Therapeutic Range of 2 Irrigated, One Non-irrigated and one Cryoablation Catheter

Abstract

Lesion characteristics including size and transmurality are important factors in the creation of conduction block with respect to catheter ablation. The energy required to create safe and effective lesions may vary from one ablation system to another. Understanding the differences in this energy requirement could allow the operator to titrate the appropriate therapy with each system - generating successful outcomes while minimizing complications. Twenty-two swine underwent an acute ablation procedure whereby 4 lesions were placed with a different catheter in each of the following areas: the left atrium (LA), along the cavo-tricuspid isthmus (CVI) and in right atrial tissue (RA). Four ablation catheters were studied: an 8mm cryoablation catheter, an 8mm standard RF catheter, a 2.5mm insulated open irrigated catheter, and a 3.5mm open irrigated RF catheter. Energy was applied for 30s with the RF catheters and 120sec with cryo, within the therapeutic range for that catheter. Lesion size, RF/Cryo characteristics, popping and other adverse events were recorded. One hundred sixty-three lesions were analyzed. There was no statistical difference between the lesion volumes created by each catheter. The lesion characteristics of the catheters are shown in Table 1 . Transmurality ranged from 75–90% with a trend toward greater transmurality with the 2.5mm irrigated catheter group. There was no evidence of tissue popping or other adverse events. These catheters when used within the therapeutic range on average created similar volume lesions but with wide variation. Cryoablation tended to create the largest lesions but was less likely to be transmural, while the 2.5mm catheter was most likely to deliver transmural lesions. Catheter comparison